A world-first report on natural compounds that directly disrupt SARS-CoV-2 viral proteins—beyond the reach of conventional antivirals.
This study focuses on three viral proteins believed to persist in the body after infection: ORF3a, ORF9b, and the Spike S1 N-terminal domain (S1-NTD).
ORF3a forms destructive “pores” in lysosomes and the Golgi apparatus, impairing the cell’s self-cleaning function (autophagy).
ORF9b fuses with TOM70, a receptor on the outer membrane of mitochondria, disrupting both immune signaling and energy production.
S1-NTD exhibits high neuroinvasiveness and has been implicated in multi-organ inflammation and autoimmune-like symptoms.
The compounds evaluated in this report are all naturally derived and have shown potential not only for mitochondrial protection, synaptic plasticity, and cytokine balance, but also for general neuroimmune homeostasis.
Our methodology combines molecular dynamics simulation (OpenMM, developed by Stanford) and force field optimization (OpenFF), with a retrained and modified version of DeepPurpose (originally developed at Harvard). This was integrated with the latest UC San Diego COVID-19 drug-target dataset (14,493 entries as of December 2024), enabling drug-level molecular screening at unprecedented speed and accuracy.
 
Key Biological Targets
Structural destabilization of viral proteins known to impair autophagy
Interference with mitochondrial outer membrane complexes (e.g., ORF9b–TOM70)
Indirect blockade of S1-NTD binding sites that impact immune and neural stability
Evaluation of antioxidant, anti-inflammatory, and neuroprotective auxiliary pathways
 
Who Should Read This Report
Individuals in good health seeking to optimize focus, cognitive endurance, and sustained energy
People experiencing brain fog, fatigue, or cognitive decline after COVID-19 infection
Those seeking a holistic strategy for post-viral neuroimmune-metabolic recovery
Users who prefer natural, low-risk, functionally backed supplements
Healthcare professionals and researchers seeking quantitative, simulation-based supplement evaluation
 
⚠ Important Precautions (Consult your doctor)
Pregnant or breastfeeding individuals
Those with a history of hormone-sensitive conditions (e.g., breast or prostate cancer)
Individuals currently taking anticoagulants, immunosuppressants, or antidepressants (possible interactions)
People sensitive to high doses of antioxidants
Individuals with severe liver or kidney disorders
 
Disclaimer
This report is for educational and informational purposes only. It does not constitute medical advice, diagnosis, or treatment.
Always consult a qualified healthcare professional before making decisions regarding supplements or health interventions.